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从基础到临床:间充质干细胞源外泌体调节骨重建的未来
  • ISSN:3029-2816(Online)3029-2808(Print)
  • DOI:10.69979/3029-2808.25.07.049
  • 出版频率:月刊
  • 语言:中文
  • 收录数据库:ISSN:https://portal.issn.org/ 中国知网:https://scholar.cnki.net/journal/search

从基础到临床:间充质干细胞源外泌体调节骨重建的未来
武海飞

赣南医科大学江西州,341000

摘要:骨骼不仅具有支撑和保护功能,还参与矿物质代谢,并为骨髓发育提供环境。其组织在生命周期中不断经历破骨与成骨的动态重塑,由破骨细胞与成骨细胞协同维持平衡,失衡则可能引发骨质疏松或骨硬化等疾病。最新研究指出,骨髓间充质干细胞(BMSCs)、成骨细胞、破骨细胞及骨细胞分泌的外泌体,在调控骨重塑方面起着重要作用。本文综述了间充质干细胞来源外泌体(MSC-Exo)在骨重建中的功能及其作用机制。

关键词:间充质干细胞;外泌体;骨重建;成骨细胞;破骨细胞

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