从基础到临床：间充质干细胞源外泌体调节骨重建的未来
武海飞

赣南医科大学，江西赣州，341000；

摘要：骨骼不仅具有支撑和保护功能，还参与矿物质代谢，并为骨髓发育提供环境。其组织在生命周期中不断经历破骨与成骨的动态重塑，由破骨细胞与成骨细胞协同维持平衡，失衡则可能引发骨质疏松或骨硬化等疾病。最新研究指出，骨髓间充质干细胞（BMSCs）、成骨细胞、破骨细胞及骨细胞分泌的外泌体，在调控骨重塑方面起着重要作用。本文综述了间充质干细胞来源外泌体（MSC-Exo）在骨重建中的功能及其作用机制。

关键词：间充质干细胞；外泌体；骨重建；成骨细胞；破骨细胞

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