EETs在神经系统疾病中的研究进展
曹金璐

扬州市江都人民医院，江苏扬州，225200；

摘要：环氧化二十碳三烯酸（epoxyeicosatrienoic acids，EETs）是由花生四烯酸经细胞色素P450环氧化酶代谢途径介导产生的代谢产物，目前已有文献证明其在神经系统中发挥多种生理作用。EETs主要包括5,6-EET、8, 9- EET、11, 12- EET和 14, 15- EET四种类型。EETs被可溶性环氧水解酶(soluble epoxide hydrolase，sEH)水解形成二氢环氧化二十碳三烯酸（DHETs），DHETs生物活性并不稳定。增强EETs表达及控制sEH对EETs的水解在神经保护中可起到重要作用。本文总结了环氧化二十碳三烯酸对神经系统的功能作用，包括调节神经元兴奋性、抑制神经细胞凋亡、减少神经炎症、降低神经毒性、促进神经功能的恢复、保护血脑屏障与增加脑血流量，以及调节水摄入、影响昼夜节律等多种生理功能。

关键词：环氧化二十碳三烯酸；EETs；神经系统；细胞凋亡；神经炎症；神经毒性；水摄入

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