AZGP1在膀胱癌发生发展及临床应用中的研究进展

沈绍晨^{（通讯作者）}

南昌大学第二附属医院健康管理中心，江西南昌，330006；

摘要：锌-α2糖蛋白1（AZGP1）是保守的分泌型糖蛋白，属于MHC-I超家族，广泛参与机体脂质代谢、细胞黏附、增殖凋亡、上皮间质转化以及肿瘤免疫微环境调控等一系列生物学过程。膀胱癌是泌尿系统最常见的恶性肿瘤，具有异质性大、复发率高、进展快、预后差别大的特点，近些年来多项临床队列和基础实验研究显示，AZGP1在膀胱癌组织里表现出明显的低表达状况，它的表达水平同肿瘤的病理分级、T分期、淋巴结转移、复发进展以及远期预后存在联系。本文从AZGP1的分子结构和生理功能、在膀胱癌中表达特点、恶性发展调控机制、临床应用前景、目前研究不足和未来发展方向等方面进行了系统的综述，为膀胱癌的精准诊断、预后评价和新型靶向疗法提供一些理论依据。

关键词：膀胱肿瘤；AZGP1；生物标志物；上皮‑间质转化；信号通路；预后

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