碱基编辑器CGBE的研究进展
林洁婧 王刚（通讯作者）

广州大学生命科学学院精准基因编辑工程中心，广东广州，510006；

摘要：碱基编辑技术作为基因组编辑领域的重要进展，不依赖于双链断裂（DSB），从而减少了基因组损伤和脱靶效应。碱基编辑器（Base Editor, BE）是一种能在特定的DNA位点实现单碱基的精确替换的技术。自2016年CBE（Cytosine Base Editor）和ABE（Adenine Base Editor）被提出以来，碱基编辑器已成为基因编辑研究的热点。CGBE（Cytosine-Guanine Base Editor）是基于CBE的进一步发展，它能够同时编辑胞嘧啶（C）和鸟嘌呤（G），拓展了碱基编辑器的应用范围。本综述将概述碱基编辑器CGBE的基本研究进展。

关键词：碱基编辑；碱基颠换编辑器；CGBE；脱氨酶

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