基于外泌体的骨缺损修复研究进展
胡欣怡 张佳昌 翁梓赫 付强 苏辉

河北北方学院，河北张家口，075000；

摘要：骨缺损的临床修复面临愈合微环境复杂、再生能力受限等挑战。外泌体作为高生物相容性的纳米囊泡，已成为该领域研究前沿。本文系统阐述不同细胞来源外泌体调控成骨分化、促进血管生成及调节免疫微环境的作用机制，探讨工程化修饰策略，并分析其与生物材料递送系统协同构建复合体系以克服单独应用局限的转化策略。外泌体及其递送系统的深度融合为骨缺损修复提供新方向。

关键词：外泌体；骨再生；工程化修饰

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