中-重度主动脉瓣狭窄患者中心房颤动的机制及临床意义研究进展
金鑫1 金银姬2

1延边大学附属医院超声医学科，吉林延边，133002；

2延边大学 护理学院，吉林延边，133002；

摘要：本研究深入剖析中-重度主动脉瓣狭窄（AS）患者并发心房颤动（AF）的潜在机制与临床意义。伴随全球人口老龄化加剧，AS 的发病率显著攀升，退行性病变已成为其主要病因。诸多研究显示在中-重度AS患者中，血流动力学的显著改变致使左心室后负荷急剧增加，进而引发左心室向心性肥厚。与此同时，神经内分泌系统的激活，尤其是肾素 - 血管紧张素 - 醛固酮系统（RAAS）的过度活化，促使心肌纤维化，并激活交感神经系统，显著增强了 AF 的易感性。尽管目前对这一领域的机制和临床意义已有一定程度的认识，但仍存在诸多亟待解决的关键问题。未来研究应着重从分子生物学层面深入探究其发病机制，挖掘潜在的治疗靶点。借助机器学习等前沿技术，有望实现对高风险患者的早期精准识别，从而制定个性化的防治策略。

关键词：主动脉瓣狭窄；心房颤动；机制；临床意义

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