Vitamin B production by intestinal flora through the cerebral-intestinal axis in the face of neuritis obliterans
Peng Xuan    Wen Huiyi    Fu Siwu

Northwest University for Nationalities，Lanzhou，Gansu，730030；

Abstract: Facial neuritis, a neurological disease, is characterized by dysfunction of the muscles responsible for facial expression. The pathogenesis of this condition involves a variety of factors, including an inflammatory response, nerve ischemia, and metabolic dysregulation.Recent studies have demonstrated that intestinal flora influence the function of both the central and peripheral nervous systems through bidirectional regulatory mechanisms of the brain-gut axis. This review will focus on the potential role of vitamin B synthesized by intestinal flora (e.g., B1, B6, B12, etc.) in facial neuritis. Vitamin B serves as an important coenzyme involved in the formation of nerve myelin and energy metabolism. Moreover, clinical studies have identified that patients with facial neuritis frequently exhibit signs of intestinal dysbiosis and diminished vitamin B levels. This observation suggests the potential for the flora-vitamin B axis to play a pivotal role in the onset and progression of the disease. This research domain offers novel insights into the prevention and treatment of facial neuritis, underscoring the necessity for further in-depth studies. These studies should investigate the specific mechanisms through which particular strains of vitamin B-producing bacteria influence facial neuritis via the brain-gut axis. Moreover, they should aim to develop suitable intervention programs.

Keywords: vitamin B; facial neuritis; intestinal flora; brain-gut axis; potential role

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